• br Discussion CML was the first malignancy to be

  2019-04-20

  

  Discussion CML was the first malignancy to be linked to a clear genetic abnormality, the Philadelphia chromosome. This chromosomal abnormality is so named because of the city in which it was first discovered and described in 1960 by Peter Nowell and David Hungerford [1]. The fusion protein result

• br Conclusion br Authors contribution br Competing

  2019-04-20

  

  Conclusion Authors’ contribution Competing interests Acknowledgments Case report Imatinib has radically changed prognosis in chronic-phase Chronic Myeloid Leukemia (CML), with 90% overall survival rate at 8yrs, and 40–70% of patients achieving a stable MMR [1]. Even better results hav

• order LY2584702 br Martyn Plummer and colleagues

  2019-04-20

  

  Martyn Plummer and colleagues (September, 2016) analyse the global burden of cancers attributable to infections in 2012. Despite the relatively low attributable proportion compared with other infectious agents, liver flukes, including and , were estimated to have caused 1300 new cases of cholangi

• br Discussion This observation reports an unusual

  2019-04-19

  

  Discussion This observation reports an unusual association of LEMS with LGL leukemia occurring in the same patient, and clearly shows that both diseases benefited from LGL leukemia therapy. Methotrexate and steroids rapidly induced hematological complete remission associated with disappearance of

• Despite taking hydroxyurea for months his

  2019-04-19

  

  Despite taking hydroxyurea for 6 months, his leukocytosis, splenomegaly, and constitutional symptoms were poorly controlled and his performance status and overall function had declined even further. There was little clinical benefit to gain by increasing the hydroxyurea dose further especially in th

• BQ-788 sodium salt br Case report A year old female presente

  2019-04-19

  

  Case report A 50-year-old female presented with splenomegaly (24 cm) and pancytopenia in Mar. 2014. A bone marrow biopsy revealed hypocellular marrow (1st BQ-788 sodium salt of R-COP (Fig. 3). Further 5 cycles of cytotoxic therapy with standard dose R-CEOP (rituximab; cyclophosphamide; epirubici

• Introduction In current rehabilitation practice for

  2019-04-19

  

  Introduction In current rehabilitation practice for most clinicians, restorative, supportive and palliative rehabilitation are the primarily courses of treatment for colorectal cancer (CRC) patients in Taiwan. When the end result of treatment for any patient is a fully functional recovery, restorat

• Introduction Osteosarcoma OS is the most common type

  2019-04-19

  

  Introduction Osteosarcoma (OS) is the most common type of bone tumor occurred in adolescents and children [1]. OS is highly malignant and accounts for about half of bone sarcomas with high potential of metastasis [2]. Treatment for OS is mainly depended on surgical operation, assisted with chemothe

• regadenoson br Discussion Studies have reported

  2019-04-19

  

  3. Discussion Studies have reported that permanent PMI using the conventional pectoral approach is impossible or contraindicated in 1–6% of patients [1–5]. In such patients, PMI via the iliac vein is considered an effective alternative. The advantages of this approach are that the wound size and

• Seg n el coeficiente de Gini que

  2019-04-19

  

  Según el coeficiente de Gini que mide la desigualdad, en la región es de 0.51, nivel de desigualdad sustancialmente más alto que otras zonas del mundo, al tener en cuenta que Estados Unidos tiene 0.378 y los países de la ocde 0.313. De ahí que el promedio simple de los valores en América Latina indi

• Cambiemos de hemisferio y procedamos a viajar

  2019-04-18

  

  Cambiemos de hemisferio y procedamos emodin viajar al Cusco del siglo xvi. La doctrina o parroquia que es de interés aquí –San Cristóbal Qolqanpata– parece haber sido administrada inicialmente por unos intermediarios apostólicos que poco o nada tuvieron que ver con la orden de San Francisco. La cabe

• br Una de las m s acres y

  2019-04-18

  

  Una de las más acres y reiteradas recriminaciones (RS)-CPP la tl provenientes de los sectores eclesiales más conservadores, ha estado fundada en el uso del instrumental teórico de origen marxista y su tesis de la lucha de clases, debido a que se le atribuye una irreconciliable incompatibilidad con

• br Introduction Cytochrome P CYP plays

  2019-04-18

  

  Introduction Cytochrome P450 (CYP) plays a key role in drug metabolism. In particular, CYP3A is highly expressed in the human liver and contributes to the metabolism of more than half of current pharmaceutical compounds [1,2]. From the viewpoint of drug-drug interactions, it is important to evalu

• br Discussion The present meta analysis of randomized

  2019-04-18

  

  Discussion The present meta-analysis of randomized trials demonstrated that treatment with AAMs is associated with an increase in non-cardiac and all-cause mortality as compared to non-arrhythmic therapy or control group. There was no significant reduction in cardiac or arrhythmic mortality betwe

• br Descripci n de las variantes Las variantes en los

  2019-04-18

  

  Descripción de las variantes Las variantes en los dos poemas estudiados a veces son leves: puntuación, acentuación o actualización de la ortografía. Pero cuando las acotaciones implican cambio de léxico o la sustitución de una parte o de un verso completo, constituyen un problema textual que ayud

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