• Interpretation The SMART course can give orthopaedic

  2019-06-27

  

  Interpretation The SMART course can give orthopaedic surgeons practising in LMICs the skills and knowledge to successfully perform flaps and reduce amputation. While this MOG (35-55) course offers a collaborative, sustainable approach to reduce global surgery disparities in amputation, future inves

• br Case report A year old man with

  2019-06-27

  

  Case report A 63-year-old man with a history of longstanding atrial fibrillation (AF) was admitted to our hospital with anterior acute myocardial infarction (AMI). Emergency cardiac catheterization revealed chronic total occlusion of the distal right coronary artery, total occlusion of the proxim

• Besides the possibility of a tumor with spontaneous regressi

  2019-06-27

  

  Besides, the possibility of a tumor with spontaneous regression seem not to be associated with tumor size, tumor number, the level of serum alpha-fetal protein presence or not of distance metastasis distance metastasis. Two common mechanisms of HCC with spontaneous regression were suggested: tumor h

• Recently denosumab demonstrated a significant delay in

  2019-06-27

  

  Recently, denosumab demonstrated a significant delay in the onset of detectable bone lesions in men with castration resistant prostate cancer compared to placebo . This could indicate some kind of efficacy of the compound as anticancer agent and consequently an indirect confirmation of the role of R

• Cisatracurium Besylate molecular br Case report His physical

  2019-06-27

  

  Case report His physical examination and basic laboratory data were normal. No organic heart disease other than dextrocardia was detected on electrocardiography, chest radiography, and echocardiography (Fig. 1). A head-up tilt test (HUT) was performed according to the ESC/ACC guidelines [7,8]. T

• La pregunta que fundamenta esta investigaci n es acerca de

  2019-06-27

  

  La pregunta que fundamenta esta investigación es acerca de la posibilidad de que los participantes de experiencias de acción colectiva urbana definan y re-definan sus pertenencias Histamine Phosphate la región y las naciones en las que se insertan. Este acercamiento a las representaciones que los su

• In primary diagnosis IKZF status

  2019-06-27

  

  In primary diagnosis IKZF1 status was not taken into account for risk group stratification. According to protocol ALL-MB-2002 regulations, risk was underestimated and patient was assigned to the SRG. Prognostic value of IKZF1 alterations in ALL, especially BCR-ABL1 negative ALL, is still debated [19

• Rabies has no cure and by the

  2019-06-26

  

  Rabies has no cure, and by the time of clinical onset it is invariably fatal. More than 95% of deaths occur in Africa and Asia, 80% of which are in people living in rural, underserved populations, most of whom are children. Community awareness about the power of preventing dog bites and of life-savi

• All statistical analyses were performed using

  2019-06-26

  

  All statistical analyses were performed using SPSS software (version 15; SPSS Inc., Chicago, IL, USA). Continuous data are expressed as mean (standard deviation) and were analyzed with two independent-samples tests. Chi-square and Fisher\'s exact tests were used for categorical data. The significanc

• br Conflict of interest br Introduction br Baseline ablation

  2019-06-26

  

  Conflict of interest Introduction Baseline ablation strategies targeting PVs It is well known that PVI was first developed to eliminate the triggers that initiate attacks of paroxysmal atrial fibrillation [1]. Subsequently, the additional function of the PV myocardium to perpetuate atrial f

• Since many decades bone tumours have stimulated imagination

  2019-06-26

  

  Since many decades, bone tumours have stimulated imagination of researchers and numerous therapeutic alternatives have been proposed [134,135, Fig. 4]. The better knowledge of OPG/RANK/RANKL system leads to the development of peptides mimicking OPG and blocking RANK–RANKL interactions [136–139]. Inh

• In our study the levels of

  2019-06-26

  

  In our study, the levels of BALP, PINP and β-CTx in the serum were significantly (pPDK1 inhibitor markers indicate that the bone formation and bone absorption occur at the same time in patients with BM. Another feature of our research was that we used BTMs clinically to predict the risk of SREs. W

• In addition our present findings demonstrated that NOACs

  2019-06-26

  

  In addition, our present findings demonstrated that NOACs may offer advantages over warfarin therapy besides efficiency and safety. The time to ECV in the present OAC-naïve patients was significantly shorter in the NOAC group compared to the VKA group. This may be explained by the delayed achievemen

• Repurposing use of approved drugs for new indications or

  2019-06-26

  

  Repurposing (use of approved drugs for new indications) or repositioning (use of drugs whose development was not continued for new indications) of existing drugs has been put forward as a method to overcome some of these issues. Indeed, drug repositioning and repurposing could lead to higher rates o

• Ivacaftor molecular Any abnormality causing a loss of functi

  2019-06-25

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

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