• br Competing interests br Acknowledgments This

  2021-03-09

  

  Competing interests Acknowledgments This work was supported by grants from Fujian Fujian Provincial Natural Science Foundation (2016J01612). Introduction Cancer is still one of the most serious diseases in the world. According to the World Health Organization (WHO), cancer is the second mo

• Dihydrofolate reductase DHFR is an excellent molecular

  2021-03-08

  

  Dihydrofolate reductase (DHFR) is an excellent molecular target for this study because it has been and is currently studied by using different molecular modeling techniques [6], [7], [8], [9]. Kerrigan et al. have reported an interesting review about recent progress in molecular dynamics simulations

• In this study EDC NHS

  2021-03-08

  

  In this study, EDC/NHS crosslinked collagen films were derivatised with VWFIIINle-containing THPs and the effect on VWF and DDR2 activity was examined. First, we investigated restoration of the binding of DDR2 and VWF A3. Cell behavior beyond simple binding was also investigated through DDR2 seroton

• br Endothelial mechanotransduction br Apoptosis br

  2021-03-08

  

  Endothelial mechanotransduction Apoptosis Death associated protein kinase Conclusion DAPK is localized to the Deferiprone australia network, and promotes actomyosin contractility. DAPK stabilizes stress fibers by phosphorylation of MLC (Bialik et al., 2004, Kuo et al., 2003). In endothe

• br Cysteine proteases as molecular targets for trypanosomati

  2021-03-08

  

  Cysteine proteases as molecular targets for trypanosomatid diseases Approaches relying on a molecular target, such as SBDD and target-based screening, have supported outstanding scientific developments in current pharmaceutical R&D. By integrating experimental and computational methods, these str

• Studies also provide evidence that cytokines such as TGF a

  2021-03-08

  

  Studies also provide evidence that cytokines such as TGF-β, a TH3-type cytokine, may also play a role in airway remodeling. Data obtained by Cohen et al suggest that TGF-β1 can induce human BSMC proliferation by increasing the expression of IGFBP-3. Hence, the mitogenic action of TGF-β1 could be rel

• sodium butyrate synthesis Acknowledgements This work was sup

  2021-03-08

  

  Acknowledgements This work was supported in part by a Scholarship Fund for Young Researchers by the Promotion and Mutual Aid Corporation for Private (2017 to S.K.), research grant from Japan Rett Syndrome Support Organization (2018 to S.K.), and MEXT-Supported Program for the Strategic Research Fou

• Studies have shown that the cultivation of

  2021-03-08

  

  Studies have shown that the cultivation of BMSCs under hypoxic conditions, treating with cytokines (such as HGF, IGF-1 and IL-6) and viral-mediated CXCR-4 gene delivery have been shown to re-establish CXCR-4 expression on the surface of stem Ferulenol receptor (Liu et al., 2010, Liu et al., 2014a,

• The COMT gene is involved in numerous psychological and phys

  2021-03-08

  

  The COMT gene is involved in numerous psychological and physiologic processes, including modulation of pain. Polymorphisms in this gene have also been associated with many painful conditions, including pain sensitivity in children. Bivariate analysis demonstrated that individuals with heterozygous C

• CK enzymes belong to a conserved family of serine

  2021-03-08

  

  CK1 enzymes belong to a conserved family of serine/threonine protein kinases that plays an important and diverse role in vesicular trafficking, DNA repair, Meptazinol HCl progression and cytokinesis in organisms from yeast to humans [15]. In multicellular organisms CK1 enzymes also regulate develop

• Another interesting finding regarding substrate selectivity

  2021-03-08

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty Hordenine at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitute a

• Early VL diagnosis makes it

  2021-03-08

  

  Early VL diagnosis makes it possible to formulate a quicker and more effective treatment against the disease, which could increase the possibility of a cure for the patients, as well as reduce the toxicity of the drugs (Coelho et al., 2009); however, conventional and molecular parasitological method

• Our study found a significant association

  2021-03-08

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P  attempted to describe the relationship between CT-features and EGFR PD 151746 status. However, only a small portion of these previous studies included the evaluation of lobulation,

• Through an unknown mechanism RING Ubox type E dimers and

  2021-03-05

  

  Through an unknown mechanism, RING/Ubox-type E3 dimers and the N-terminal tail have been shown to function as a modulator of full E3 ubiquitin ligase activity [27]. LRSAM1 promotes a significant enhancement in the formation of the high-molecular-weight products or E3 activity when the RING domain is

• A structural explanation for how RBR RING s handle

  2021-03-05

  

  A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon

15978 records 683/1066 page Previous Next First page 上5页 681682683684685 下5页 Last page