• br Methods br Results br Discussion The measurement of intra

  2022-05-26

  

  Methods Results Discussion The measurement of intraocular pressure was made with a commercially available rebound tonometer, the Tonovet®. In our studies, Tonovet® underestimated the intraocular pressure in both animal models, being this effect more pronounced in the rat. To study the effe

• Mouse iPSC Chemical Reprogramming Cocktails Kit sale br Mate

  2022-05-26

  

  Materials and methods Results Discussion Ghrelin is required for maintenance of glucose homeostasis under fasting conditions, and GHSR-null mice have low fasting blood glucose levels [5], [9]. In this study, we found that restoration of GHSR in nodose ganglion neurons rescued low fasting bl

• br Materials and methods br Results and discussion br

  2022-05-26

  

  Materials and methods Results and discussion Conclusion Altogether, our data provide an unexpected insight into Cx26 trafficking pathway and gap junction assembly in the cochlea. Since many of the disease-causing mutations in GJB2 impair the trafficking and delivery of Cx26 to the cell surf

• The present study demonstrates that SNAP exhibits a toxic ef

  2022-05-26

  

  The present study demonstrates that SNAP 37889 exhibits a toxic effect to these specific cell types, which is independent of endogenous expression of GAL receptor subtypes and leads to apoptosis. This conclusion is based on our findings that, although HMCB, HL-60 and SH-SY5Y cell lines differ in GAL

• br FGF FGFR pathway as predictive factor Several studies

  2022-05-26

  

  FGF/FGFR pathway as predictive factor Several studies have identified FGFR1 amplification as the major predictive factor of response to FGFR inhibitors [26], [27]. However, in a recent study on lung cancer cell lines with ponatinib, FGFR1 mRNA and protein expression, together with FGF2 and FGF9 m

• br General features of FGFRs

  2022-05-26

  

  General features of FGFRs and inhibitors Conclusion Given the critical role of FGFRs in the progression of tumors, the co-crystal structures of these kinases in complex with inhibitors are determined in order to clarify the mechanism of actions and explore new efficient inhibitors. This manusc

• With the aim to identify

  2022-05-26

  

  With the aim to identify potential novel targets in CVD, we applied proteome analyses on vascular tissue of these frequently used mouse models of atherosclerotic disease in the presence and/or absence of diabetes. Potential targets for intervention identified with this approach were validated in hum

• NGS substitution linkage analysis and haplotype reconstructi

  2022-05-25

  

  NGS substitution linkage analysis and haplotype reconstruction was previously only used for short genome segments and not in the context of antiviral resistance. We optimized this approach to cover a complete viral protein and major DAA target, enabling us to investigate resistance associated NS3P h

• The following are the supplementary data

  2022-05-25

  

  The following are the supplementary data related to this article. Transparency Document Acknowledgements Introduction Nitric oxide (NO) is an important signaling molecule mediating several physiological functions including vasodilation, platelet anti-aggregation, inhibition of interstitial

• Annexin A ANXA a member of annexin superfamily is a

  2022-05-25

  

  Annexin A7 (ANXA7), a member of annexin superfamily, is a Ca2+- and phospholipid-binding protein and possesses GTPase activity [5,6]. The ANXA7 gene is located on human chromosome 10q21, where multiple potential tumor suppressor genes exist. Homozygous ANXA7 (−/−) knockout mice showed a lethal pheno

• Recently it was found that

  2022-05-25

  

  Recently, it was found that hypoxia results in the phosphorylation of β-catenin at Y654 in a Src-dependent manner (Xi et al., 2013). All β-catenin phosphorylated at this residue was found complexed with Hif1α and it was demonstrated that this β-catenin phosphorylation was required for Src to promote

• Various inhibitors have been developed to target molecules

  2022-05-25

  

  Various inhibitors have been developed to target molecules present in these pathways. They include both man-made monoclonal duvelisib as well as small molecule membrane permeable inhibitors that often target kinases or phosphatases [5], [338], [348], [364]. In summary, these pathways are frequently

• As natural ligands of GPR several long chain

  2022-05-25

  

  As natural ligands of GPR120, several long chain polyunsaturated fatty acids (Lc-PUFAs) have been demonstrated to modulate the 3T3-L1 adipogenic differentiation. However, the effects of the Lc-PUFAs are inconclusive. DHA is shown to inhibit, promote or even not affect the differentiation of preadipo

• br Introduction High dose niacin or nicotinic acid has been

  2022-05-25

  

  Introduction High dose niacin, or nicotinic acid, has been used as an athero-protective drug for more than 50 years (Carlson, 2005, Offermanns, 2006). When taken in pharmacological doses (>1g/day), the nicotinic Luciferase Reporter Assay Kit form of niacin modulates plasma lipid profiles includin

• To overcome these limitations investigators have

  2022-05-25

  

  To overcome these limitations, investigators have developed novel strategies for identifying and purifying gonadotropes from transgenic mouse models. For example, FSH-producing gonadotropes have been tagged in vivo with a transgenic cell surface antigen (H-2Kk) so that they can be purified in vitro

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