• ICLs represent of all generated DNA

  2022-07-12

  

  ICLs represent ICL Inducers in Cancer Therapy Nitrogen mustards with aromatic substituents (chlorambucil, melphalan) or a bioactivatable phosphoramide group (cyclophosphamide) were one of the first identified DNA crosslinkers. These agents are still used in combined schemes for the therapy of chr

• br Author Contributions br Acknowledgments We thank

  2022-07-12

  

  Author Contributions Acknowledgments We thank Hiroyuki Miyoshi, Makoto Nakanishi, Yoshikazu Johmura, Yuki Okada, Yoshinori Makino, Takashi Sutani, and Katsuhiko Shirahige for kindly providing materials and technical information, Shiho Takahashi-Kariyazono for technical advice, and all members

• br Methods br Results br

  2022-07-12

  

  Methods Results Discussion Peptide therapeutics represents a unique class of biopharmaceuticals that continues to evolve in drug discovery and development. We and others have been particularly interested in bioengineering innovative pGC-A and/or pGC-B peptide activators. This has been succe

• Considering its role in regulating cytoskeletal dynamics the

  2022-07-12

  

  Considering its role in regulating cytoskeletal dynamics, the Rho kinase effector ROCK has been particularly implicated in tumor metastasis. The ROCK inhibitors Y27632 and fasudil have been extensively studied in cancer and beneficial effects have been observed in many types of cancers (Kale et al.,

• Sodium valproate Historically pharmacological investigations

  2022-07-12

  

  Historically, pharmacological investigations have been carried out by first identifying a biological response to a ligand, and then subsequently using that ligand to identify the receptor(s) responsible for the response (Wilson et al., 1998). However, this approach needed revision with the discovery

• Targeting MCTs is likely to have

  2022-07-12

  

  Targeting MCTs is likely to have dramatic effects on lactate-dependent metabolic symbiosis described in the previous paragraphs. A plethora of MCT inhibitors have been described, including α-cyano-4-hydroxycinnamate (CHC) [59], organomercurials [60], stilbene disulfonates [60], and other second-gene

• Consistent with other studies on

  2022-07-12

  

  Consistent with other studies on the metabolic effects of an OM3 enriched diet [26,104,105], irrespective of gender, the lowest glucose levels were seen in the Bob-Cat groups fed OM3 diet. Sexual dimorphism was observed in insulin levels. The highest average levels were in the HFD fed [Tg(CAT)±] mal

• br Excitatory amino acid transporter

  2022-07-11

  

  Excitatory amino Desformylflustrabromine hydrochloride mg transporter-mediated glutamate transport Early studies detailing the presence of uptake systems capable of transporting glutamate and aspartate into neurons and glia represented a critical step in the overall task of demonstrating that l-

• pHi regulation in astrocytes has been examined

  2022-07-11

  

  pHi regulation in astrocytes has been examined primarily in cell culture rather than in situ. Two HCO3−-dependent transporters, NBC and Na+-driven Cl-HCO3 exchange (NDCBE), have been described [10,16], in addition to Cl-HCO3 anion exchange (AE) [96]. Culture studies indicate that NHE is the principa

• br Introduction Glucose homeostasis is primarily regulated b

  2022-07-11

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β Senexin A sale is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory

• Insulin de sensitization has been observed

  2022-07-11

  

  Insulin de-sensitization has been observed in the brains of people with AD [51], [52], [53] and we previously demonstrated that the GLP-1 analogue liraglutide was able to reverse this [54]. Importantly, SP2509 insulin de-sensitization correlates well with cognitive decline [15], [55] and with tau p

• Extending time action is another

  2022-07-11

  

  Extending time action is another strategy to increase in vivo efficacy. Twice daily administration of the unacylated analogs herein caused greater body weight loss in DIO mice than the equivalent dose administered as a single daily injection, suggesting that protracted time action should yield more

• Taken together previous data suggest that

  2022-07-11

  

  Taken together, previous data suggest that ghrelin signaling is causally linked to alcohol use and may regulate alcohol seeking and consummatory behaviors [[66], [67], [68]]. As such, the ghrelin system may represent a therapeutic target for AUD. Here, we provide a narrative review of the existing l

• In addition to inactivation of Notch

  2022-07-11

  

  In addition to inactivation of Notch, we found that the combination of BTZ and GSI-I downregulated ERK phosphorylation in ALK+ ALCL cells, and we speculate this may occur through the inhibition of upstream regulators of the ERK pathway. These findings emphasize the functional complementation of the

• There is a dual inducer of both

  2022-07-11

  

  There is a dual inducer of both galanin and super-threshold pain. First, injury-induced pain may stimulate galanin secretion. After peripheral nerve injury, the galanin expression level was upregulated in dorsal root ganglion (DRG), dorsal horn and hypothalamic arcuate of rats [25], [28], [33]. The

16058 records 398/1071 page Previous Next First page 上5页 396397398399400 下5页 Last page