• Introduction The burden of cardiovascular disease CVD is

  2024-09-13

  

  Introduction The burden of cardiovascular disease (CVD) is undisputed, accounting for approximately a third of global deaths (17.5 million people in 2012) (WHO, 2012). Atherosclerosis leads to the development of coronary heart disease (CHD) which accounts for more than 40% of these deaths (WHO, 201

• br Experimental procedures br Results br Discussion

  2024-09-13

  

  Experimental procedures Results Discussion Our biophysical and cellular analyses of mutant Aβ1–42 peptides support a role of the N-terminus of Aβ in peptide aggregation and toxicity. We demonstrate that double mutations constructed to humanize the rodent Aβ1–42 sequence result in a signific

• br Concluding remarks Enhanced membrane binding upon

  2024-09-13

  

  Concluding remarks Enhanced membrane binding upon calcium stimulation in kainic acid suggests a pre-requisite step that involves a conformational change in LOX. This might facilitate it to tether to the membrane and regulate enzyme activity. The calcium binding loops and the putative active site

• Introduction Inflammasomes are large cytosolic protein compl

  2024-09-12

  

  Introduction Inflammasomes are large cytosolic protein complexes with multiple components that trigger a rapid immune response against pathogen-associated molecular pattern Salmeterol xinafoate (PAMPs) during pathogen infections or damage-associated molecular pattern molecules (DAMPs) during tissu

• Analyses of brain CSCs isolated from pediatric and

  2024-09-12

  

  Analyses of 46619 australia CSCs isolated from 24 pediatric and six adult brain tumors detected ALDH levels proportional to tumor type and aggressiveness. ALDH-expressing cells (ALDH+) formed spheroids while ALDH1 pharmacological inhibition by a combination of DEAB and RA decreased significantly sph

• According to average serum fat content of g L

  2024-09-12

  

  According to average serum fat content of 6.9 g/L (Phillips et al., 1989) and serum dioxin level from individuals exposed to dioxins as the result of accidents in Seveso (Needham et al., 1997), Taiwan (Guo et al., 2004) and Vietnam (The Tai et al., 2011) the median serum concentration of TCDD would

• PKA signalling in the http www

  2024-09-12

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the EZLink NHS-Biotin Kit to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nuc

• The extent to which GPCR oligomerization is a

  2024-09-12

  

  The extent to which GPCR oligomerization is a regulated process still remains unclear. Reported effects of ligands on both GPCR homo- and heteromers are highly variable and depend on GPCR subtypes and the specific ligand used. According to our data, chronic treatment of mice with both paroxetine or

• Compounds were profiled for their

  2024-09-12

  

  Compounds – were profiled for their inhibitory activity against dipeptidyl peptidase-IV Activity and/or Structure Homologues (DASH) [e.g. DPP2, DPP8 and DPP9] and non-DASH [eg. post-proline cleaving enzyme (PPCE), neutral endopeptidase (NEP), aminopeptidase P (APP), aminopeptidase N (APN)] enzymes.

• Autotaxin has been linked to

  2024-09-12

  

  Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer rosavin australia [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being over-expressed

• Chronic inflammation is associated with both initiation

  2024-09-12

  

  Chronic inflammation is associated with both initiation and progression of many neoplastic conditions [149], and ATX may be a player in the process. ATX/LPA signaling is positively correlated with the invasive and metastatic potential of several cancers including melanoma, breast cancer, ovarian can

• To help ensure the fidelity of mitosis and cytokinesis cells

  2024-09-12

  

  To help ensure the fidelity of mitosis and cytokinesis cells monitor these processes and delay cell cycle progression in response to certain defects. The spindle assembly checkpoint (SAC) is a surveillance system which delays 66 4 onset until a bipolar spindle has been correctly assembled (Lara-Gonz

• br Acknowledgements This work was supported

  2024-09-12

  

  Acknowledgements This work was supported by the Victorian Government Operational Infrastructure Support Program. KAB is supported by the Mavis Robertson Fellowship from the National Breast Cancer Foundation (NBCF; ECF-16-004), by an NBCF Novel Concept Award (NC-14-011), and by NHMRC project grant

• br Introduction Rhamdia quelen jundi Silurifomes Heptapterid

  2024-09-12

  

  Introduction Rhamdia quelen (jundiá, Silurifomes, Heptapteridae) is a neotropical catfish widely distributed in Central and South America (Silfvergrip, 1996). This species shows high potential for the aquaculture industry, due to an elevated growth rate, good carcass yield, and easy reproduction

• Maduramicin is a polyether ionophore antibiotic that

  2024-09-11

  

  Maduramicin is a polyether ionophore antibiotic that has the smallest margin of safety between the maximum authorized dosage and the minimum toxic concentration. Clinical signs of maduramicin intoxication are similar to that of other ionophores, often causing feed refusal, anorexia, respiratory dist

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