• Several alterations have been or can be associated to the

  2023-09-25

  

  Several alterations have been or can be associated to the decreased tolerance of steatotic liver to I/R injury. Previous studies demonstrated that upregulation of the mitochondrial uncoupling protein-2 (UP2) is strictly related to the increase of I/R injury in steatotic liver [4]. UPR induction is c

• Gene regulation of MMPs is influenced

  2023-09-25

  

  Gene regulation of MMPs is influenced by the transcription factor activating factor-1 (AP-1). AP-1 complexes are heterodimers of proteins of the two proto-oncogene families (jun and fos) and have j 14 in the promoter region of MMPs, as well as in genes mediating inflammatory responses. The transcrip

• While we chose to divide

  2023-09-25

  

  While we chose to divide our etiologies into three categories, it should be noted that such division has certain limitations. Even though URIs and the common cold are considered mainly viral in origin and rhinosinusitis mainly bacterial in origin,26, 27 there is considerable overlap between these co

• Regarding progression free survival analyzing clinical trial

  2023-09-25

  

  Regarding progression free-survival, analyzing 12 clinical trials, we demonstrated that the use of antiangiogenic treatment results in a statistically longer PFS with a pooled HR of 0.76 (95% CI 0.65–0.89, p the progression-free survival results were largely unchanged. The improvement of PFS and th

• br Summary and future br Introduction

  2023-09-25

  

  Summary and future Introduction Androgen activity is critical for a wide range of developmental and physiological responses and is especially important in male sexual differentiation and maturation. The biological activity of androgens occurs through binding to the androgen receptor (AR) and t

• br Depletion of serum amino acids

  2023-09-25

  

  Depletion of serum amino acids Currently, the only anticancer agents that directly target amino Romidepsin metabolism are bacterial l-asparaginases (from Escherichia coli and Erwinia chrysanthemi), which are FDA-approved for treatment of pediatric and adult ALL. A potential complication of using

• With regard to the correlation between

  2023-09-25

  

  With regard to the correlation between -rearrangements and thromboembolic events, Zer et al. reported a VTE rate of 36% in a cohort of 98 patients with ALK-positive NSCLC. Of note, VTE was also associated with shorter overall survival (HR: 5.71, =0.01) . Only few others have investigated NSCLC drive

• br Introduction Alcohol i e ethanol is

  2023-09-25

  

  Introduction Alcohol, i.e., ethanol, is absorbed into the blood from the stomach to the small intestine, then distributed throughout the body. The metabolism of alcohol converting to acetic Dovitinib Lactate basically involves two enzymes; alcohol dehydrogenase converting ethanol to acetaldehyde

• ADOR immunoreactivity was high in parasympathetically innerv

  2023-09-25

  

  ADOR immunoreactivity was high in parasympathetically-innervated smooth muscle, namely the iris sphincter muscle and the ciliary muscle. No ADOR immunoreactivity was noted in the sympathetically-innervated iris dilator muscle. Immunoreactivity against all four ADORs was noted in the ciliary epitheli

• br Results br Discussion Today enzymes play important

  2023-09-25

  

  Results Discussion Today, enzymes play important roles in various fields. A good assay for enzyme activity is of great value, especially when it has good specificity, sensitivity, reproducibility and economy. ADK is the first identified enzyme in the metabolic pathway of adenosine salvage [15,

• A previous study reported that the

  2023-09-23

  

  A previous study reported that the serotonergic mechanism was involved in the psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 field (Matsumoto et al., 2004). Sumitaka Inoue et al. (Inoue et al., 2014) reported that pretreatment with a 5-HT1A receptor partial

• br Materials and methods br

  2023-09-23

  

  Materials and methods Results Discussion Despite the relative complexity of immunotherapy, such treatment may have an important role, in conjunction with other therapies in the treatment of cancer refractory to conventional treatments alone. Clinical studies have recently shown that adding

• Of the many different types of DNA lesions

  2023-09-23

  

  Of the many different types of DNA lesions, DNA double strand breaks (DSBs) are amongst the most deleterious. It has been suggested that a single unrepaired DSB may be sufficient to induce cell death (Bennett et al., 1993), whereas misrepaired DSBs can result in loss of genetic information, potentia

• There are in contrast many studies demonstrating that sex

  2023-09-23

  

  There are in contrast many studies demonstrating that sex steroids modulate nmda receptor processing of stimuli related to reproduction and this correlates with the observation that steroid receptors and aromatase are expressed in many brain nuclei that are part of the olfactory, visual and auditory

• CORT induced hippocampal damage has been implicated in depre

  2023-09-23

  

  CORT-induced hippocampal damage has been implicated in depression, aging and long-term glucocorticoid therapy. Therefore, finding a drug that can protect hippocampal neurons from the adverse effects of CORT could have significant clinical benefits. In this regard, we tested the potential protective

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