• br Conclusions Several lines of evidence have been establish

  2024-08-07

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute inositol phosphatase injury to initial downregulation of ADK, rise in extracellular adenosine, changes in astro

• br Conclusions and future directions Translation of the

  2024-08-07

  

  Conclusions and future directions Translation of the therapy to human MG will require a substitute adjuvant for IFA. Most human vaccines use aluminum salts (alum) as adjuvants. Both IFA and alum selectively promote antibody dominated Th 2 immune responses, rather than T killer cell dominated Th 1

• An AXL decoy receptor with enhanced GAS binding

  2024-08-07

  

  An AXL decoy receptor with enhanced GAS6-binding properties, MYD1, was engineered as a therapeutic tool to disrupt GAS6/AXL signaling in vivo (Kariolis et al., 2014). MYD1 was shown to block metastasis of human ovarian cancer Triamcinolone and a murine breast cancer cell line in grafting assays in

• Further analysis sought to understand the mechanism

  2024-08-07

  

  Further analysis sought to understand the mechanism associated with the autotaxin-mediated increase of miR-489-3p in circulation. Based upon sequence complementarity, DIANA TarBase predicted miR-489-3p targets MAPK2K1, or MEK1, an oncogene widely dysregulated in cancer (Fig. 4A). To test this relati

• Introduction The first use of the term autophagy

  2024-08-07

  

  Introduction The first use of the term “autophagy” by a French physiologist, M. Anselmier, in a short article describing the effects of fasting in mice published in 1859, took place almost a century before Christian De Duve described it from a mechanistic point of view in a symposium on lysosomes i

• br Introduction Throughout early prophase I meiotic cells in

  2024-08-07

  

  Introduction Throughout early prophase I, meiotic cells intentionally generate DSBs as part of a stringently controlled process to initiate homologous recombination (HR). HR is a critical DSB repair pathway that ultimately permits the exchange of genetic information between homologous chromosomes

• br Conclusions In summary aromatase mRNA expression in the b

  2024-08-06

  

  Conclusions In summary, aromatase mRNA expression in the Methylcobalamin of A. leptorhynchus shows a similar distribution pattern as seen in other teleosts with expression detected in the forebrain and the pituitary gland. The lack of aromatase mRNA expression in the midbrain and hindbrain of A.

• Mitochondrial dysfunction resulting from mtDNA abnormalities

  2024-08-06

  

  Mitochondrial dysfunction resulting from mtDNA abnormalities may trigger retrograde signaling pathways from the mitochondrion to the nucleus, which regulate the expression of genes involved in diverse cellular processes, including metabolism, stress responses, tumor progression, nutrient sensing, li

• Hyperactivity of the hypothalamus pituitary

  2024-08-06

  

  Hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis, which is well described in MDD (Pariante and Lightman, 2008, Marques et al., 2009), is also observed in AD and results in increased glucocorticoid (GC, cortisol in primates) levels in blood and CSF (Davis et al., 1986, Martignoni et al.

• However in recent years advanced experiments and

  2024-08-06

  

  However, in recent years advanced experiments and findings are emerging to give us more detailed information on Aβ-membrane interactions. Several reviews have provided background on the fibrillation of Aβ and the Aβ-membrane interactions [[18], [19], [20], [21], [22]]. In this review, we mainly focu

• br Regulation of BCAA catabolism The BCAA catabolic

  2024-08-06

  

  Regulation of BCAA catabolism The BCAA catabolic system is equipped in mammalian cells to dispose of excess BCAAs, presumably resulting in relatively stable concentrations of BCAAs in blood and tissues in humans. The main BCAA catabolic pathway is localized in the mitochondria of all tissues. The

• The ORR obtained with crizotinib on our cohort

  2024-08-06

  

  The ORR obtained with crizotinib on our cohort was low compared to other studies, such as the prospective studies of A. Shaw et al. (ORR = 65% in second line), B. Solomon et al. (ORR = 74% in first line) and the more comparable large retrospective study of M. Duruisseaux et al. on the French CLINALK

• Spectroscopic techniques are powerful biophysical tools

  2024-08-06

  

  Spectroscopic techniques are powerful biophysical tools used in the study of biomolecular structures, including those of proteins. UV–Vis methylphenidate hcl spectroscopy makes use of absorption property of the protein peptide backbone at around 218 nm, and aromatic amino acid residues primarily at

• In a recent series of studies from

  2024-08-06

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat AN-2728 wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced contr

• br Conclusions The present data

  2024-08-06

  

  Conclusions The present data suggest that homeostatic balance of the cortical/hippocampal adenosinergic tone is necessary for normal working memory function and any deviation appears to impair performance – either as a consequence of A2AR under-activation when adenosine levels are reduced or due

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