• To establish whether replacement of lost podocytes by

  2018-10-24

  

  To establish whether replacement of lost podocytes by RPCs could influence CKD outcome, we traced podocyte regeneration to compare mice that underwent proteinuria remission with those that developed persistent proteinuria and CKD using two different lineage-tracing strategies. By tracking podocytes

• ESC CMs can be subdivided into atrial and

  2018-10-24

  

  ESC-CMs can be subdivided into atrial and ventricular CMs (Burridge et al., 2012). It has been documented that the expression of the α-isoform of myosin heavy chain (α-MHC), MLC2a, and MLC1a become restricted to the atrium during murine development (Zammit et al., 2000). Here, we employed MLC2a and

• Gpr or T cell death associated gene Tdag is

  2018-10-24

  

  Gpr65, or T cell death-associated gene 8 (Tdag8), is a proton/acid-activated GPCR (Choi et al., 1996; Wang et al., 2004). Whereas GPR65 had not been linked to HSPC transitions, it was reported to be a pro-apoptotic factor in glucocorticoid-induced lymphocyte apoptosis (Malone et al., 2004) and to re

• The definition of marker combinations in neural

  2018-10-24

  

  The definition of marker combinations in neural stem cell biology has been hampered by the dearth of information linking markers and the underlying lineage-defining biology. LPA is of particular interest as it suggests lipids as a new class of molecules co-defining stem cell entities, and indeed lip

• Another question is the heterogeneity within and between

  2018-10-24

  

  Another question is the heterogeneity within and between organoids, which seems common to all the protocols developed so far but has not yet been studied in detail. Several processes, such as progenitor proliferation, cell differentiation, and ontogenetic cell death, could be potential sources of or

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank Ms. Y. Ogata for technical assistance. Financial support for this research was provided by the Uehara Memorial Foundation, Takeda Science Foundation, the Naito Foundation, the Ministry of Education, Culture, Sports, Scien

• purchase baicalein Epigenetic modification by active DNA dem

  2018-10-24

  

  Epigenetic modification by active DNA demethylation or histone demethylation has been shown to facilitate iPSC induction in human and mouse (Huangfu et al., 2008a, 2008b). Tet1, a DNA methylcytosine dioxygenase, can facilitate iPSC induction by promoting Oct4 demethylation and re-activation, and eve

• br Introduction Myelination of the CNS of

  2018-10-24

  

  Introduction Myelination of the CNS of mice occurs mainly within the first 4 post-natal weeks when oligodendrocyte progenitor cells (OPCs) differentiate into myelin-forming oligodendrocytes. After this period, adult OPCs of divergent developmental origins remain scattered throughout the CNS paren

• The goal of this study

  2018-10-24

  

  The goal of this study was to understand how synthetic hydrogels influence global biological function compared with standard 2D or 3D cell-culture formats. Vascular morphogenesis was chosen as a model biological system, and a bioinformatics approach was employed to provide genome-wide analysis for H

• pak4 br Experimental Procedures br Author Contributions br A

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank Qian Yu for assistance with the induction of pluripotent stem cells and Dr. Bing Song for assistance with the flow cytometry assays. We thank Profs. Xiaofang Sun and Yong Fan of the Key Laboratory for Major Obstetric Dise

• It has been proposed that the dynamic balance

  2018-10-24

  

  It has been proposed that the dynamic balance between longer, more toxic Aβ peptides, in particular the 42-amino-acid Aβ42, and shorter Aβ peptides is a more significant determinant of disease rho kinase inhibitor and progression than total Aβ production (Findeis, 2007; Kuperstein et al., 2010). Th

• br Results br Discussion The transplant created chimera enab

  2018-10-24

  

  Results Discussion The transplant-created chimera enables us to investigate the effects of human neural EPI-001 Supplier in the adult mouse spinal cord (Chen et al., 2015). Using this model, we have shown that neural cells from sALS patient iPSCs, especially astrocytes, integrate into the mou

• O4I1 The electrical properties of cells were

  2018-10-24

  

  The electrical properties of O4I1 were recently analyzed by EIS during the differentiation of stem cells (Angstmann et al., 2011; Bagnaninchi and Drummond, 2011; Venkatanarayanan et al., 2013). These pioneering works have demonstrated a possibility of using changes in impedance as a biomarker for st

• Inflammation is one of the main features of

  2018-10-24

  

  Inflammation is one of the main features of neurodegenerative diseases (Campbell, 2004). Having methods available that generate human astrocytes that are responsive to inflammation allows for the modeling of this component of the disease using patients\' cells. Previous studies reported the generati

• The Langmuir isotherm suggests monolayer adsorption on a hom

  2018-10-24

  

  The Langmuir isotherm suggests monolayer adsorption on a homogeneous surface with a finite number of adsorption sites and without any interaction between the adsorbed molecules (Acharya et al., 2009a, 2009b). The Langmuir equation relates solid phase adsorbate concentration (qe), the uptake, to the

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