• Since many decades bone tumours have stimulated imagination

  2019-06-26

  

  Since many decades, bone tumours have stimulated imagination of researchers and numerous therapeutic alternatives have been proposed [134,135, Fig. 4]. The better knowledge of OPG/RANK/RANKL system leads to the development of peptides mimicking OPG and blocking RANK–RANKL interactions [136–139]. Inh

• In our study the levels of

  2019-06-26

  

  In our study, the levels of BALP, PINP and β-CTx in the serum were significantly (pPDK1 inhibitor markers indicate that the bone formation and bone absorption occur at the same time in patients with BM. Another feature of our research was that we used BTMs clinically to predict the risk of SREs. W

• In addition our present findings demonstrated that NOACs

  2019-06-26

  

  In addition, our present findings demonstrated that NOACs may offer advantages over warfarin therapy besides efficiency and safety. The time to ECV in the present OAC-naïve patients was significantly shorter in the NOAC group compared to the VKA group. This may be explained by the delayed achievemen

• Repurposing use of approved drugs for new indications or

  2019-06-26

  

  Repurposing (use of approved drugs for new indications) or repositioning (use of drugs whose development was not continued for new indications) of existing drugs has been put forward as a method to overcome some of these issues. Indeed, drug repositioning and repurposing could lead to higher rates o

• Ivacaftor molecular Any abnormality causing a loss of functi

  2019-06-25

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

• br In their Comment on

  2019-06-25

  

  In their Comment on the use of antenatal corticosteroids to reduce preterm infant deaths, Kishwar Azad and Anthony Costello advise “extreme caution” before scale-up in low-income settings. They emphasise maternal sepsis as a concern but cite only one trial in which dexamethasone resulted in a sign

• La Brev ssima relaci n de la destruyci n

  2019-06-25

  

  La Brevíssima relación de la destruyción de las Indias de fray Bartolomé de las Casas, fechada el 8 de diciembre de 1542, se publica en el año 1552 (“… fue rogado e importunado que destas postreras pusiesse algunas por brevedad por escrito”). Finalmente es condenada en 1660 por el Tribunal de la Inq

• Para finalizar focaliza se o hospital l

  2019-06-25

  

  Para finalizar focaliza-se o hospital, lócus de embate desta pesquisa, e recorre-se aos direcionamentos de Donadone, em estudo envolvendo consultores e gerentes no país. Afirma o autor que “[…] é possível visualizar um processo de guerra cultural onde Dehydroepiandrosterone what visão financeira da

• El n mero de correspondiente al segundo

  2019-06-25

  

  El número 59 de , correspondiente al segundo semestre de 2014, ofrece la sección Temas y Problemas de Nuestra América, en el que se encuentran artículos relacionados con asuntos de gran relevancia actual. En primer lugar, el texto “Nuevas narrativas constitucionales en Bolivia y Ecuador: el buen viv

• Chloramphenicol Apart from their association with severe pai

  2019-06-25

  

  Apart from their association with severe pain and reduced quality of life, SREs require substantial healthcare resource utilization (HRU) in their treatment and management. Previous retrospective studies have attempted to quantify various aspects of the burden of SREs across specific tumor types/cou

• T wave was similar in

  2019-06-25

  

  T-wave was similar in seven patients. The terminal portion of the T-wave was negatively inverted compared with that at baseline in five patients on using ER-2000®. Representative example of sinus rhythm with T-wave discordance is shown in online Supplementary Fig. S3. T-wave morphology was different

• Bay 65-1942 HCl salt molecular Como es l gico hay un persona

  2019-06-25

  

  Como es lógico, hay un personaje que hace de contrapunto Bay 65-1942 HCl salt molecular esa posición y que por ello mismo la vuelve, por efecto de una diférance (Derrida 1972b), mucho más significativa. Lily, la mujer de Nicolás, no comprende ni lo más mínimo la fascinación que ejerce sobre su marid

• En esta columna al mismo tiempo que se

  2019-06-25

  

  En esta columna, al mismo tiempo que se congratulaban de informar la generosa donación de Andrew Carnegie, de 250 mil dólares para una biblioteca en La Habana, señalaban la inexorable presencia del poder foráneo estadounidense. Una vez inaugurada la República, afirmaba La Lucha: “Después del 20 de m

• La cr nica compart a espacio con una

  2019-06-25

  

  La crónica compartía espacio con una nota que anunciaba la falta de alimentos y los bombardeos de la aviación somocista que obligaban NP118809 los capitalinos a huir de la ciudad, “mientras los ‘muchachos’ del Frente Sandinista lograron el control de varios sectores en el sur y el sureste de Managua

• br India is rapidly becoming urbanised

  2019-06-24

  

  India is rapidly becoming urbanised. By 2030, around 40% of the country\'s population will live in urban areas. The extent to which India\'s health system can provide for this large and growing city-based population will determine the country\'s success in achieving universal health coverage and i

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